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12.1 Mechanism of Action. The precise mechanism of action of baclofen is not fully understood. Baclofen inhibits both monosynaptic and polysynaptic reflexes at the spinal level, possibly by decreasing excitatory neurotransmitter release from afferent terminals, although actions at supraspinal sites may also occur and contribute to its clinical Onset of Action (Minutes) Duration of Action (Hours) Route of Admin. Side Effects Comments Baclofen 6-8 4-6 Oral Drowsiness, Dizziness, nausea, confusion, headache, constipation, urinary frequency Tizanidine Unknown 4-8 Oral Dry mouth, dizziness, somnolence, asthenia, constipation, blurred vision Unless otherwise indicated. References stendra 200 mg reviews Onset Analgesic Duration Typical Initial Adult Dosing for Acute Pain Typical Initial Pediatric Dosing for Acute Pain; Acetaminophen IV: 5-10 minutes: 4-6 hours 50 kg: 12.5 mg/kg every 4 hours or 15 mg/kg every 6 hours; 50 kg: 650 mg every 4 hours or 1,000 mg every 6 hours. 2y and adolescents; 50kg: refer to adult dosing; 50kg However, oral baclofen is often not effective in the early stages of acute baclofen withdrawal, due to its slow onset of action (3 4 days) and time to peak effect (5 10 days). This is especially pertinent with acute withdrawal following ITB, as the onset of withdrawal may occur rapidly (most typically within 12 24 h).