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Ty [20,21]. For instance, the F-box family (33 members in Drosophila [22]) contains a diverse group of proteins that recruit specific substrates to the Cul1 E3 ligase via the Skp1 adaptor, which binds both the NH2terminus of Cul1 and the F-box domain [11,23]. The RING domain-containing Roc proteins are essential for CDL function and are also encoded by a gene family [19]. Humans and C. elegans con